Current status of preimplantation diagnosis for single gene disorders
نویسندگان
چکیده
منابع مشابه
current status of preimplantation genetic diagnosis
since its first clinical application in early 90s, preimplantation genetic diagnosis (pgd) has became a powerful diagnostic procedure in clinical practice for avoiding the birth of an affected child as well as increasing the assisted reproductive technologies (art) outcome . the technique involves the screening of preimplantation embryos for chromosomal abnormalities in certain indications such...
متن کاملCurrent Status of Preimplantation Genetic Diagnosis
Since its first clinical application in early 90s, preimplantation genetic diagnosis (PGD) has became a powerful diagnostic procedure in clinical practice for avoiding the birth of an affected child as well as increasing the assisted reproductive technologies (ART) outcome . The technique involves the screening of preimplantation embryos for chromosomal abnormalities in certain indications such...
متن کاملCurrent status of preimplantation genetic diagnosis in Japan
This is a retrospective study aimingto clarify the current status of preimplantation genetic diagnosis (PGD) in Japan. Our data were collected from 12 facilities between September 2004 and September 2012, and entered into a database. A majority of PGD in Japan was performed for balanced structural chromosomal abnormalities in couples with recurrent miscarriage. PGD for monogenic diseases was pe...
متن کاملThe minisequencing method: an alternative strategy for preimplantation genetic diagnosis of single gene disorders.
We have applied a new method of genetic analysis, called 'minisequencing', to preimplantation genetic diagnosis (PGD) of monogenic disorders from single cells. This method involves computer-assisted mutation analysis, which allows exact base identity determination and computer-assisted visualization of the specific mutation(s), and thus facilitates data interpretation and management. Sequencing...
متن کاملPolar body-based preimplantation genetic diagnosis for Mendelian disorders.
Introduced >20 years ago, the use of polar bodies (PBs), involving sequential removal and genetic analysis of the first (PB1) and second (PB2) PB, provides the option for pre-embryonic diagnosis, when the objection to the embryo biopsy procedures makes preimplantation genetic diagnosis (PGD) non-applicable. PB-based approach has presently been utilized in PGD for genetic and chromosomal disorde...
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ژورنال
عنوان ژورنال: Reproductive BioMedicine Online
سال: 2003
ISSN: 1472-6483
DOI: 10.1016/s1472-6483(10)61744-0